ISSN 1662-4009 (online)

ey0020.9-15 | Obesity and Insulin/Glucose Metabolism | ESPEYB20

9.15. Insulin and body mass index decrease serum soluble leptin receptor levels in humans

C Sommer , KG Vangberg , GH Moen , DM Evans , S Lee-Odegard , IK Blom-Hogestol , L Sletner , AK Jenum , CA Drevon , HL Gulseth , KI Birkeland

Brief summary: This pooled study, including five cross-sectional or intervention studies (n=24–823) and using publicly available data from genome-wide association studies (GWAS) to perform Mendelian randomization, investigated the influence of glucose, insulin, body fat, body mass index (BMI), food intake, and physical activity on serum soluble leptin receptor (sOb-R) levels. The authors showed that insulin and BMI were associated with decreased serum sOb-R level...